Its therapeutic potential has been explored in the treatment of various conditions such as pulmonary problems, cancer, sepsis and Alzheimer’s disease. It has also been the subject of scientific interest for over 50 years, given its anti-inflammatory, antioxidant, anticancerous, antiepileptic, antidepressant, immunomodulatory, neuroprotective, antiapoptotic, and antiproliferative effects.
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Zingiberaceae) with a long history of use as a traditional remedy in Chinese and Ayurvedic medicine. Overall, conclusion suggests that developed PEGylated nanoemulsions present an acceptable delivery system for parenteral administration of curcumin, being effective in preserving its stability and antioxidant capacity at the level highly comparable to the initial findings.Ĭurcumin is a dietary polyphenolic compound derived from turmeric (lat. Results from the pharmacokinetic pilot study implied the PEGylated nanoemulsions improved plasma residence of curcumin 20 min after intravenous administration, compared to the non-PEGylated nanoemulsion (two-fold higher) or curcumin solution (three-fold higher). The nanoemulsion carrier has been proven safe by the MTT test conducted with MRC-5 cell line, and effective on LS cell line. In vitro release testing proved that PEGylated phospholipids slowed down the curcumin release from nanoemulsions. Moreover, antioxidant activity remained intact, as demonstrated by DPPH (IC50 values 0.078–0.075 mg/mL after two years) and FRAPS assays.
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After two years of storage at room temperature, all formulations remained stable.
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Curcumin-loaded nanoemulsions showed mean droplet size about 105 nm, polydispersity index <0.15, zeta potential of −40 mV, and acceptable osmolality of about 550 mOsm/kg. Experimental design setup helped development of nanoemulsion templates with critical quality attributes in line with parenteral application route. The current study describes the experimental design guided development of PEGylated nanoemulsions as parenteral delivery systems for curcumin, a powerful antioxidant, as well as the evaluation of their physicochemical characteristics and antioxidant activity during the two years of storage.